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https://repository.ntt.edu.vn/handle/298300331/1

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Đang hiển thị 1 - 20 của tổng số 2662 kết quả

2D-QSAR studies on MexAB-OprM efflux pump inhibitors of Pseudomonas aeruginos : Bachelor Theses
(Nguyen Tat Thanh University, 2020) Nguyen, Truong Khanh Vy; Phan, Thien Vy (M.S Pharm.)
These days, the rate of antimicrobial resistance (AMR) in Gram-Negative bacteria is increasing rapidly. According to an exhaustive review commissioned by UK government, globally, approximately 700,000 deaths can be attributed to AMR each year. Hence, efflux pump has been found to be related multi-drug resistance in clinical isolate as well as MexAB-OprM. MexAB-OprM is the most important multi-drug efflux system of P. aeruginosa due to the wide resistance on antibiotics. Many studies discovered efflux pump inhibitors (EPIs) that are able to combine with antibiotics, which is one of the most potential therapies. Thus, the main point of this study is to build a 2D–QSAR models, which have predictive capabilities for efflux pump inhibitory activities of natural compounds and clinical medicines.
2D-QSAR studies on MexAB-OprM efflux pump inhibitors of Pseudomonas aeruginos : Graduate Thesis for Pharmacist, Majors of Medicine Administration and Supply
(Nguyen Tat Thanh University, 2020) Nguyen, Truong Khanh Vy; Phan, Thien Vy (Scientific instructor)
Result and discussion: This study had totally five QSAR models with dependent value was MPC8, which were created by different descriptors. The validation results revealed that R2 values and Q2 value of all models were surprisingly greater than 0.80 and 0.77, respectively. In addition, the other values such as RMSE, R2pred, 𝑟𝑚 ̅̅2̅ and ∆r2m were come up to validation criteria. Two best models of five were LVFX and AZT_1 would be applied to virtual screening database. As a result, there were 15 compounds and 07 compounds had predicted MPC8 less than 10 µM in LVFX model and AZT_1 model, respectively, also, all of them met Five rules of Lipinski. On the other hand, five substances from Drugbank database were forecasted to have predicted MPC8 under 10 µM . Additionally, the predicted MPC8 value under 10 µM (G-9 (spergulin A) from Glinus oppositifolius.
3D pharmacophore model studies on ACRB efflux pump inhibitors of Escherichia coli : Bachelor Theses
(Nguyen Tat Thanh University, 2020)
Resistance to antibiotics poses a major global threat according to the World Health Organization. There are various ways in which bacterium can develop its resistance to an antibiotic and efflux pump is one of the major mechanisms. AcrB of Escherichia coli is the main efflux pump. Hence, efflux pump inhibitors (EPIs) is a promising strategy to restore antibacterial potency. This study focuses on potential inhibitors of AcrB on Escherichia coli. The virtual screening approach built in this study is 3D-pharmacophore, which is used to screen potential inhibitors that are studied in laboratory.
3D pharmacophore model studies on ACRB efflux pump inhibitors of Escherichia coli : Graduate Thesis for Pharmacist, Majors of Medicine Administration and Supply
(Nguyen Tat Thanh University, 2020) Tran, Thuy Vy; Phan, Thien Vy (Scientific instructor)
In silico method is not only economic but also saving time. Moreover, it is used to screen specific compounds so that it will contribute to develop drug target. 3D-pharmacophore models on AcrB inhibitors helps to design and predict AcrB inhibitors which can apply to find new drugs.
3D-Pharmacophore model studies on MexB efflux pump inhibitor of Pseudomonas aeruginosa : Bachelor Theses
(Nguyen Tat Thanh University, 2020) Dinh, Nguyen Thuy Duyen; Phan, Thien Vy (M.S. Pharm.)
In recent years, antimicrobial resistance rates in gram-negative bacteria are increasing rapidly and efflux pump has been found to be related to multi-drug resistance in clinical isolates. MexAB-OprM tripartite efflux pump, which belongs to the RND superfamily, are the main multi-drug efflux system of Pseudomonas aeruginosa because of the broad resistance on antibiotics. With the discovering of efflux pump inhibitors (EPIs), the combination between these and antibiotics is one of the most promising therapies. Therefore, the main research direction focuses on developing MexAB-OprM pump inhibitors to restore antibiotic activity.
3D-Pharmacophore model studies on MexB efflux pump inhibitor of Pseudomonas aeruginosa : Final Report Scientific Research Project Of Student In 2020
(Nguyen Tat Thanh University (Faculty of Pharmacy), 2020) Dinh, Nguyen Thuy Duyen; Phan, Thien Vy (Hướng dẫn)
From the database of 139 substances in 18 scafford collected from 20 scientific papers, 6 3D Pharmacophore models were built based on ligand: 4 models based on MPC8 value and 2 models based on IC50 value. Then validate models based on sensitivity, specificity, accuracy and GH score and choose the 3 best models to virtual screening on large databases such as DrugBank, Traditional Chinese Medical. In which Model (3) has 4 features: 2 hydrophobic centroids and 2 hydro bonding acceptors HHaa. Model (4) with 4 features: 1 aromatic ring, 1 hydrophobic centroid and 2 hydro bonding acceptors RHAA. Model (5) with 4 feartures: 3 hydrophobic centroids and 1 hydro bonding acceptors HHHa.
3D-Pharmacophore model studies on MexB efflux pump inhibitor of Pseudomonas aeruginosa : Final Report Topics Student Science Research Program In 2020 / ; Phan Thien Vy Science instructor
(Nguyen Tat Thanh University (Faculty of Pharmacy), 2020) Dinh, Nguyen Thuy Duyen; Phan, Thien Vy, M.S.Pharm. (Scientific instructor)
Research for screening compounds which satisfy all 3 models, will be conduct screening through Qsar model and molecular docking studies on MexAB-OprM crystal structures to find the binding pocket of these. Some suggestions and solutions.
3D-Pharmacophore model studies on MexB efflux pump inhibitor of Pseudomonas aeruginosa : Graduate Thesis for Pharmacist, Majors of Medicine Administration and Supply
(Nguyen Tat Thanh University, 2020) Dinh, Nguyen Thuy Duyen; Phan, Thien Vy (Scientific instructor)
3D-Pharmacophore models are successfully built and screened for potential substances. The study suggests screening through Qsar and Docking models, then conducting in vitro and in vivo tests to determine their true biological activity on impacted target and discover additional compounds with MexAB-OprM inhibitory activity
3D-pharmacophore models studies on acrb efflux pump inhibitors of escherichia coli : Dissertation final report scientific research project of student in 2020
(Nguyen Tat Thanh University (Faculty of Pharmacy), 2020) Tran, Thuy Vy; Phan, Thien Vy, M.S.Pharm. (Scientific instructor)
A Closer look into recent economy, Whether or not Vietnam faces a 10-year crisis?
(Nguyen Tat Thanh University, 2019) Dinh, Cong Tuan; Sun, YingJun
From 2018, the global economy began to grow strongly and synchronously, but as 2018 passed, the development momentum has become slower, faded, along with biased growing trends. The US economy has accelerated thanks to fiscal stimulus policies early this year, while the economy of the EU, Britain, Japan and China began to weaken. These differences will continue to exist in 2019 and Vietnam is not excluded. This study is a closer look into Vietnamese economy from 2007 up to now & prediction to the upcoming period. Objective: The present study aims at giving predictions & recommendations to sustain Vietnam’s economy in the next years based on analyzing multiple economic indicators such as: economic growth rate, inflation, unemployment rate, import and export throughout the period 2007 – 2018. Material and methods: General information about the Vietnam’s economy & crisis trend was collected from the documentation provided by National Financial Committee as well as economic websites. Then, the authors analyzed & made comparisons between years to years & created tables to show them clearly. Secondary data, such as theoretical frameworks and literature, were obtained from reference books, scientific books, scientific articles and peer reviewed journals. Results: The economy since 2007 has been so volatile: the economic growth rate fell erratically, unpredictably; unemployment & inflation rate are still really big problems while import, export & investment have prospered gradually. Conclusions: Vietnam's economy is on a good & rapid growth path, with many economic advantages. However, in essence, Vietnam is still a young economy, so we need to be well prepared to cope with major economic fluctuations that may occur, possibly next year – the beginning year of the 10-year crisis period.
A light gradient boosting machine-based method for predicting the dynamic response of functionally graded plates
(Nguyen Tat Thanh University, 2024) Do, Thi Thanh Dieu; Nguyen, Hoang Yen
The primary objective of this paper is to efficiently predict the dynamic response of functionally graded plates using LightGBM – a light gradient boosting machine, without reliance on supplementary analysis tools. To obtain the optimal LightGBM model, a dataset comprising 1,000 pairs of input and output is generated through iterations using a combination of isogeometric analysis (IGA) and third-order shear deformation plate theory (TSDT). In this model, the input is represented by a power index which governs the material distribution of the plate, and the output comprises 200 values illustrating deflection over time. To demonstrate the effectiveness of LightGBM in terms of accuracy and computational time, the results obtained by the proposed model are compared to those achieved with the optimal ANN, XGBoost models, and IGA.
A Mixed-Method Study of ICT Labour Market in Ho Chi Minh City
(Nguyen Tat Thanh University, 2024) Duong, Thi Kim Xoa; Nguyen, Tuan Anh; Tran, Binh Hau; Nguyen, Phuong Thong
The purpose of this study is to provide insights into Information and Communication Technology (ICT) labour market in Ho Chi Minh City – the most important centre of VietnameseICT industry. The study was conducted using an innovative mix of semi-structured interview, online survey, desk research, and content analysis methods. Qualitative and quantitative data on enterprise profiles, business directions, employment situation, employment prospect, and job profiles in the industry were collected and analysed to provide a view of the ICT labour market and the ICT employers in Ho Chi Minh City. As it is probably the most comprehensive survey of the ICT labour market for Ho Chi Minh City, the data has been used for the development of a labour market information system.
A simple non-enzymatic protocol for isolation and culture of mesenchymal stem cells from adipose tissues
(Nguyen Tat Thanh University, 2018) Nguyen, Thi Phuong; Nguyen, Huu Hung
Mesenchymal stem cells (MSCs) are multipotent stem cells – ability to differentiate into several cell types. Previous studies have showed a high number of these cells can be found in adipose tissue. This study has established a simple protocol for isolation and culture of MSCs from mouse adipose tissue using minimal requirements. With non-enzymatic approach, we successfully isolated and cultured the MSCs. Isolated MSCs were identified through morphology and ability of differentiation into adipocyte-like cells under the presense of stimuli in the culture medium.
Ẩm thực truyền thống Huế trong phát triển du lịch tại thành phố Huế : Luận văn Thạc sĩ Du lịch; Mã ngành: 8840101
(Trường Đại học Nguyễn Tất Thành (Khoa Du lịch), 2023) Đào, Thị Thùy Ninh; Nguyễn, Văn Hoàng, TS.
Đề tài được thực hiện với mục tiêu nhận diện và hướng đến việc khai thác hiệu quả ẩm thực truyền thống Huế trong phát triển du lịch tại thành phố Huế.
An effective protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow
(Nguyen Tat Thanh University, 2018) Nguyen, Thi Phuong; Nguyen, Huu Hung
Bone marrow is known as the main source of isolated mesenchymal stem cells. This study has demonstrated a protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow (mBM) with minimal requirement. The cells were harvested from the tibias and femurs, and then cultured in Dulbecco’s modified Eagle’s medium supplemented with fetal bovine serum. The mBM-MSCs were isolated by media changing every 8 hours in 24 hours of culture and sub-culture. Target cells subsequently were regconized by adipogenic differentiaton posibility. The study also focused on descript a simple procedure to culture BM-MSCs and the results obtained following the procedure.
An investigation into how mindfulness practice might improve listening comprehension of English learners in Viet Nam
(Nguyen Tat Thanh University, 2024) Nguyen, Hoai Phuong
This study investigated the effect of short mindfulness exercises on the listening comprehension of Vietnamese students learning English. Research participants (N = 190) were randomly divided into two groups: the experimental group who received three five-minute mindfulness sessions before listening tests and the control group who received the mindfulness intervention only before the last listening test. The results showed a significant interaction effect between the group variable and test scores, indicating that mindfulness meditation can enhance listening comprehension of the experimental compared to the control group. These findings align with previous studies on the positive effects of mindfulness on listening comprehension of foreign language learners. This study suggests that mindfulness may be a valuable tool not only in education in general but also in language learning and teaching.
An investigation of vocabulary learning perceptions and strategies of first-year English as a Foreign Language university learners
(Nguyen Tat Thanh University, 2025) Nguyen, Quynh Tran Chau; Tran, Thi Thao Phuong
This study explored vocabulary learning strategies and perceptions among 50 first-year EFL students at Hue University. Using questionnaires and interviews, it was found that learners mainly used Memory and Cognitive Strategies, while Social Strategies were rarely applied. Students struggled with collocations, phrasal verbs, and pronunciation due to limited English exposure and personal factors like shyness. The study recommends fostering collaborative learning and personalized vocabulary instruction to improve acquisition, offering practical implications for teaching and curriculum development.
Analysis of digital marketing activities of topzone high-end technology store chain : Graduate thesis : Business Administration, academic year 2019 - 20222
(Trường Đại học Nguyễn Tất Thành (Khoa Quản trị kinh doanh), 2022) Trinh, Thi Thuy Duong; Tang, Thị Bich Hien, MA
Find out the current state of digital marketing at Topzone high-end technology store chain. Evaluate And Make Recommendations For Digital Marketing Of TopZone High-End Technology Store Chain
Analysis of digital marketing activities of topzone high-end technology store chain : Khóa luận tốt nghiệp, chuyên ngành Quản trị Kinh doanh
(Đại học Nguyễn Tất Thành (Khoa Quản trị Kinh doanh), 2022) Tran, Thi Thuy Duong; Tang, Thi Bich Hien, MA (Instruct)
Find out the current state of digital marketing at Topzone high-end technology store chain. Evaluate And Make Recommendations For Digital Marketing Of TopZone High-End Technology Store Chain
Analyzing genetic diversity of chloroplast genomes in Liliales
(Nguyen Tat Thanh University, 2022) Do, Hoang Dang Khoa
Liliales is a monocotyledonous order and contains both photosynthetic and mycoheterotrophic species that distribute locally or worldwide. In this study, the genetic diversity of chloroplast genomes in Liliales was explored regarding their nucleotide diversity and repeated composition. The analysis of nucleotide diversity revealed various hotspots in large and small single-copy regions whereas the IR regions had low sequence divergence. Although each family has specific hotspots, the rps15-ycf1 region was commonly found as a highly variable area in the cpDNA of observed taxa. In the cpDNA of Liliales, mononucleotide simple sequence repeat (SSR) is the most common type. The majority of SSRs are located in non-coding regions. Similarly, more long repeats were found in non-coding areas than in coding sequences. Additionally, the complement repeat exceeds forward type in the cpDNA of Liliales. The highest number of long repeats was found in Corsia dispar whereas that of SSRs was detected in Smilax china. The results of nucleotide diversity and repeat analyses provided fundamental information for further studies on population genetics, molecular marker development and evolutionary history of Liliales.

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