Bachelor Theses
Duyệt
Duyệt Bachelor Theses theo Chủ đề "3D pharmacophore"
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Tài liệu 3D pharmacophore model studies on ACRB efflux pump inhibitors of Escherichia coli : Bachelor Theses(Nguyen Tat Thanh University, 2020)Resistance to antibiotics poses a major global threat according to the World Health Organization. There are various ways in which bacterium can develop its resistance to an antibiotic and efflux pump is one of the major mechanisms. AcrB of Escherichia coli is the main efflux pump. Hence, efflux pump inhibitors (EPIs) is a promising strategy to restore antibacterial potency. This study focuses on potential inhibitors of AcrB on Escherichia coli. The virtual screening approach built in this study is 3D-pharmacophore, which is used to screen potential inhibitors that are studied in laboratory.