Comparison of oral efficacy between PPIs and H2RAs in subjects for prevention and monitoring of peptic ulcer-associated recurrence rates from 1985 to 2021: A systematic review and meta-analysis
Năm xuất bản
2023
Nhan đề tạp chí
ISSN
Nhan đề tập
Nhà xuất bản
Nguyen Tat Thanh University
Tóm tắt
Currently, although there are many randomized controlled trials comparing the effectiveness of proton pump inhibitors and H2-antihistamines in relation to peptic ulcer disease, meta-analytical studies on this topic are still limited and conclusions have not come to consensus. Therefore, a meta-analysis of randomized controlled trials evaluated by the Cochrane Collaboration tool is essential. From January 1st, 1985, to May 31st, 2022, the study was carried out on three databases: Pubmed, Cochrane, and Embase. Statistics are expressed as odds ratios, with confidence intervals of 95 %, and a random effects model is used. Results: Proton pump inhibitors increase the effectiveness of reatment more than H2-antihistamines. Specifically, on prevention subjects = 0.15 (95 % CI: 0.05-0.44), patients who are monitored for relapse rates without medication = 0.92 (95 % CI: 0.75-1.14), and with medication = 0.50 (95 % CI: 0.31-0.80). In conclusion, proton pump inhibitors are the first-line medicine for ulcer prevention and post-healing monitoring.
Mô tả
12 p.
Từ khóa chủ đề
Meta-analysis, Ulcer prevention, Ulcer recurrence, Peptic ulcer disease, Loét dạ dày - tá tráng
Trích dẫn
Nguyen Tat Thanh University. (2023). Journal of Science and Technology - NTTU, Volume 5, Issue 3. ISSN 2615-9015