Comparison of oral efficacy between PPIs and H2RAs in subjects for prevention and monitoring of peptic ulcer-associated recurrence rates from 1985 to 2021: A systematic review and meta-analysis

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dc.contributor.authorCao, Kim Xoa
dc.contributor.authorTran, Vo Ngoc Minh
dc.contributor.authorNguyen, Diem Kieu
dc.date.accessioned2024-08-23T06:57:00Z
dc.date.accessioned2024-08-29T02:16:53Z
dc.date.available2024-08-23T06:57:00Z
dc.date.available2024-08-29T02:16:53Z
dc.date.issued2023
dc.description12 p.
dc.description.abstractCurrently, although there are many randomized controlled trials comparing the effectiveness of proton pump inhibitors and H2-antihistamines in relation to peptic ulcer disease, meta-analytical studies on this topic are still limited and conclusions have not come to consensus. Therefore, a meta-analysis of randomized controlled trials evaluated by the Cochrane Collaboration tool is essential. From January 1st, 1985, to May 31st, 2022, the study was carried out on three databases: Pubmed, Cochrane, and Embase. Statistics are expressed as odds ratios, with confidence intervals of 95 %, and a random effects model is used. Results: Proton pump inhibitors increase the effectiveness of reatment more than H2-antihistamines. Specifically, on prevention subjects = 0.15 (95 % CI: 0.05-0.44), patients who are monitored for relapse rates without medication = 0.92 (95 % CI: 0.75-1.14), and with medication = 0.50 (95 % CI: 0.31-0.80). In conclusion, proton pump inhibitors are the first-line medicine for ulcer prevention and post-healing monitoring.
dc.identifier.citationNguyen Tat Thanh University. (2023). Journal of Science and Technology - NTTU, Volume 5, Issue 3. ISSN 2615-9015
dc.identifier.issn2615-9015
dc.identifier.urihttps://repository.ntt.edu.vn/handle/298300331/50180
dc.language.isoen
dc.publisherNguyen Tat Thanh University
dc.relation.ispartofseriesVol.5, No. 3
dc.subjectMeta-analysis
dc.subjectUlcer prevention
dc.subjectUlcer recurrence
dc.subjectPeptic ulcer disease
dc.subjectLoét dạ dày - tá tráng
dc.titleComparison of oral efficacy between PPIs and H2RAs in subjects for prevention and monitoring of peptic ulcer-associated recurrence rates from 1985 to 2021: A systematic review and meta-analysis
dc.typeArticle

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