Cytotoxic activity of Combretum quadrangulare leaf extracts on HepG2 cancer cell line
Tệp tin
Năm xuất bản
2018
Nhan đề tạp chí
ISSN
Nhan đề tập
Nhà xuất bản
Nguyen Tat Thanh University
Tóm tắt
Studies on anticancer using plant extracts/compounds are promising. However, information regarding in vitro cytotoxicity is incompleted. Herein, this study aims to evaluate the cytotoxicity potentials of hexan:ethyl acetate (50:50, v:v) and ethanol extracts of Combretum quadrangulare leaves on HepG2 cancer cell line. Using cell viablity MTT assay, hexan: ethyl acetate and ethanol extracts were defined as potential cytotoxicity with IC50 at 38 and 47 µg/mL respectively. In addition, by microscopy observation, we found that morphology of the cells apparently change in a dose and time dependent manner. The data showed in this study shed new light for further investigation of the anticancer effect of C. quadrangulare extracts and its compounds.
Mô tả
3 p.
Từ khóa chủ đề
Combretum quadrangulare, Extract, Cytotoxicity, HepG2, MTT, Dòng tế bào ung thư HepG2
Trích dẫn
Trường Đại học Nguyễn Tất Thành. (2018). Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành [Journal of Science and Technology - NTTU], (01). ISSN 2615-9015