Docking studies of AcrB efflux pump inhibitors on Escherichia coli : Bachelor Theses

dc.contributor.advisor	Phan, Thien Vy (M.S Pharm.)
dc.contributor.author	Dao, Nhut Linh
dc.date.accessioned	2025-06-13T09:02:09Z
dc.date.available	2025-06-13T09:02:09Z
dc.date.issued	2020
dc.description	51 p.
dc.description.abstract	Multidrug resistance in bacteria has become a threat to public health care over the world. One of the bacteria with a high rate of resistance in antibiotics is Escherichia coli. The most important resistance mechanism to antibiotics in E. coli is through a tripartite AcrAB-TolC pump system that belongs to the RND superfamily. AcrB plays a major role in this system. There are two binding pockets on the AcrB pump (proximal binding pocket and distal binding pocket) where subtracts bind and effect to AcrB. Therefore finding these pump inhibitors which can interfere with two binding pockets is imperative. Most EPIs cannot be used for a clinical trial because of high toxicity. Therefore docking is used as an initial screening method to find potential EPIs which low toxicity and can use for further experiments such as in vitro, in vivo, even if clinical trial.
dc.identifier.uri	https://repository.ntt.edu.vn/handle/298300331/406
dc.language.iso	en
dc.publisher	Nguyen Tat Thanh University
dc.subject	Escherichia coli
dc.subject	AcrB efflux pump inhibitors
dc.subject	Docking studies
dc.title	Docking studies of AcrB efflux pump inhibitors on Escherichia coli : Bachelor Theses
dc.type	Thesis