Investigation of crosslinked hydrogel comprising papain for lesion recovery acceleration

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dc.contributor.authorNguyen, Ngoc Sao Mai
dc.date.accessioned2024-09-17T09:17:04Z
dc.date.available2024-09-17T09:17:04Z
dc.date.issued2024
dc.description11 p.
dc.description.abstractPapain is a common protease exhibiting antioxidant and anti-inflammatory activities. Papain can be extracted from seeds, leaves or latex of papaya (Carica papaya L.). It is involved in accelerating wound healing process. Hydrogels are widely used in biomedical applications such as tissue engineering, drug delivery system, and wound healing. Cross-linked hydrogels containing papain are more aqueous, durable and promising devices to minimize recovering time of lesions. Ingredients of HPMC hydrogels were investigated and immobilized with papain. The hydrogel thickness, moisture content, Fourier transform infrared, drug content and in vitro papain release were characterized. The formula of 0.5 g papain, 5 g HPMC, 5 g CA, 7.5 g glycerin, 5 g P407, 0.3 g nipagin M and EtOH quantum satis (q.s) 100 g resulted in hydrogels 0.8 mm of thickness, 3.83 % of moisture. FTIR analysis confirmed papain incorporation into prepared hydrogels. The FE-SEM examination revealed a good distribution of papain on the hydrogel and size of papain was (5-10) µm. In addition, from 2.6652 % to 5.1021 % of papain was released from the hydrogel within 60.
dc.identifier.citationNguyen Tat Thanh University. (2024). Journal of Science and Technology - NTTU, Volume 7, Issue 3. ISSN 2615-9015.
dc.identifier.issn2615-9015
dc.identifier.urihttps://repository.ntt.edu.vn/handle/298300331/25
dc.language.isoen
dc.publisherNguyen Tat Thanh University
dc.relation.ispartofseriesTạp chí Khoa học và công nghệ - Đại học Nguyễn Tất Thành; Volume 7, Issue 3
dc.subjectPapain
dc.subjectHydrogel
dc.subjectPhysicochemical characteristics
dc.subjectWound healing
dc.subjectChữa lành vết thương
dc.subjectĐặc tính lý hóa
dc.titleInvestigation of crosslinked hydrogel comprising papain for lesion recovery acceleration
dc.typeArticle

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