3D-Pharmacophore model studies on MexB efflux pump inhibitor of Pseudomonas aeruginosa : Final Report Scientific Research Project Of Student In 2020
| dc.contributor.advisor | Phan, Thien Vy (Hướng dẫn) | |
| dc.contributor.author | Dinh, Nguyen Thuy Duyen | |
| dc.date.accessioned | 2023-03-24T09:01:08Z | |
| dc.date.accessioned | 2024-08-14T02:41:57Z | |
| dc.date.available | 2023-03-24T09:01:08Z | |
| dc.date.available | 2024-08-14T02:41:57Z | |
| dc.date.issued | 2020 | |
| dc.description | 50 p. | vi_VN |
| dc.description.abstract | From the database of 139 substances in 18 scafford collected from 20 scientific papers, 6 3D Pharmacophore models were built based on ligand: 4 models based on MPC8 value and 2 models based on IC50 value. Then validate models based on sensitivity, specificity, accuracy and GH score and choose the 3 best models to virtual screening on large databases such as DrugBank, Traditional Chinese Medical. In which Model (3) has 4 features: 2 hydrophobic centroids and 2 hydro bonding acceptors HHaa. Model (4) with 4 features: 1 aromatic ring, 1 hydrophobic centroid and 2 hydro bonding acceptors RHAA. Model (5) with 4 feartures: 3 hydrophobic centroids and 1 hydro bonding acceptors HHHa. | vi_VN |
| dc.identifier.uri | https://repository.ntt.edu.vn/handle/298300331/3369 | |
| dc.language.iso | vi | vi_VN |
| dc.publisher | Nguyen Tat Thanh University (Faculty of Pharmacy) | vi_VN |
| dc.subject | Pseudomonas aeruginosa | vi_VN |
| dc.subject | 3D-Pharmacophore | vi_VN |
| dc.subject | MexB efflux | vi_VN |
| dc.title | 3D-Pharmacophore model studies on MexB efflux pump inhibitor of Pseudomonas aeruginosa : Final Report Scientific Research Project Of Student In 2020 | vi_VN |
| dc.type | Technical Report | vi_VN |