Phan, Thien Vy (M.S. Pharm.)Dinh, Nguyen Thuy Duyen2025-06-132025-06-132020https://repository.ntt.edu.vn/handle/298300331/40750 p.In recent years, antimicrobial resistance rates in gram-negative bacteria are increasing rapidly and efflux pump has been found to be related to multi-drug resistance in clinical isolates. MexAB-OprM tripartite efflux pump, which belongs to the RND superfamily, are the main multi-drug efflux system of Pseudomonas aeruginosa because of the broad resistance on antibiotics. With the discovering of efflux pump inhibitors (EPIs), the combination between these and antibiotics is one of the most promising therapies. Therefore, the main research direction focuses on developing MexAB-OprM pump inhibitors to restore antibiotic activity.enPseudomonas aeruginosa3D-PharmacophoreMexB efflux3D-Pharmacophore model studies on MexB efflux pump inhibitor of Pseudomonas aeruginosa : Bachelor ThesesThesis