Phan, Minh Hoang (M.S.)Tran, Thanh Ngoc2025-06-252025-06-252023https://repository.ntt.edu.vn/handle/298300331/45270 p.Hydroxychavicol, a compound with multiple biological activities such as anti-inflammatory, antioxidant, and anticancer effects, was successfully synthesized from eugenol at the laboratory scale. The optimal demethylation conditions involved AlCl₃ and pyridine in acetonitrile, yielding up to 89%. Structural confirmation was performed by MS and NMR, and product purity reached 97.113% (GC-MS). This synthesis lays the foundation for scaling up and exploring hydroxychavicol derivatives.vi-VNEugenolHydroxychavicolKhử methylPhổ khối (MS)Phổ cộng hưởng từ hạt nhân (NMR)Sắc ký khí – khối phổ (GC-MS)DemethylationOptimizationArticle